Hepatic Drug Dosage Calculator
Adjust drug dosages based on liver function using Child-Pugh score and hepatic extraction ratios.
Child-Pugh Parameters
mg/dL
g/dL
Drug Parameters
mg
hours
Child-Pugh Classification
Class C
Score: 11 points - Severe hepatic impairment
📊Child-Pugh Score
11
⚖️Adjustment Factor
50%
💊Adjusted Dose
250 mg
📈1-Year Survival
45%
Score Breakdown
Bilirubin: 2 points
Albumin: 2 points
INR: 2 points
Ascites: 3 points
Encephalopathy: 2 points
Dosing Recommendations
Dose Reduction: 250 mg every 8 hours
Interval Extension: 500 mg every 16.0 hours
Adjusted Daily: 750 mg/day (vs 1500 mg/day normal)
Protein Binding Warning
Low albumin (2.8 g/dL) may increase free drug fraction. Consider additional dose reduction for highly protein-bound drugs.
Clinical Warning
Hepatic dosing is complex and drug-specific. This calculator provides general guidance. Always consult current drug references and clinical pharmacists for specific drugs.
Child-Pugh Classification Reference
| Class | Score | Severity | 1-Year Survival | Typical Adjustment |
|---|---|---|---|---|
| A | 5-6 | Mild | 100% | Usually no adjustment |
| B | 7-9 | Moderate | 81% | 25-50% dose reduction |
| C | 10-15 | Severe | 45% | 50-75% reduction or avoid |