Hepatic Drug Dosage Calculator
Adjust drug dosages based on liver function using Child-Pugh score and hepatic extraction ratios.
Important Health Disclaimer
This calculator provides general health information based on standard medical formulas and WHO guidelines. Results are for informational and educational purposes only and should not be considered as professional medical advice, diagnosis, or treatment recommendations.
For health concerns, medical conditions, fitness plans, or dietary decisions, please consult with qualified healthcare professionals, licensed physicians, registered dietitians, or certified fitness trainers who can evaluate your individual health status and medical history.
Individual health needs vary significantly. These calculations are general estimates and may not be appropriate for everyone, especially those with existing medical conditions, pregnant women, children, or elderly individuals.
Not a substitute for professional medical advice
Child-Pugh Parameters
Drug Parameters
Child-Pugh Classification
Class C
Score: 11 points - Severe hepatic impairment
Score Breakdown
Bilirubin: 2 points
Albumin: 2 points
INR: 2 points
Ascites: 3 points
Encephalopathy: 2 points
Dosing Recommendations
Dose Reduction: 250 mg every 8 hours
Interval Extension: 500 mg every 16.0 hours
Adjusted Daily: 750 mg/day (vs 1500 mg/day normal)
Protein Binding Warning
Low albumin (2.8 g/dL) may increase free drug fraction. Consider additional dose reduction for highly protein-bound drugs.
Clinical Warning
Hepatic dosing is complex and drug-specific. This calculator provides general guidance. Always consult current drug references and clinical pharmacists for specific drugs.
Child-Pugh Classification Reference
| Class | Score | Severity | 1-Year Survival | Typical Adjustment |
|---|---|---|---|---|
| A | 5-6 | Mild | 100% | Usually no adjustment |
| B | 7-9 | Moderate | 81% | 25-50% dose reduction |
| C | 10-15 | Severe | 45% | 50-75% reduction or avoid |
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sources
- •World Health Organization (WHO) — Global health metrics, disease classification, and nutritional standards. who.int
- •Centers for Disease Control and Prevention (CDC) — Health statistics, BMI guidelines, and disease prevention data. cdc.gov
- •National Institutes of Health (NIH) — Medical research, clinical guidelines, and health calculators. nih.gov
- •Mayo Clinic — Clinical health information, disease reference, and wellness guidance. mayoclinic.org
For a complete list of all references used across the site, visit our full sources page.
Editorial Note
MyCalcBuddy Editorial Team
This page is maintained as an educational calculator reference.
Formula Source: WHO Health Metrics Standards
by World Health Organization