Allosteric Cooperativity Calculator
Analyze allosteric cooperativity using the Monod-Wyman-Changeux (MWC) concerted model
MWC Model Parameters
Ratio of T to R state in absence of ligand
Fractional Saturation
45.31%
R State (Active)
51.60%
T State (Inactive)
48.40%
Apparent Hill Coefficient
3.009
Cooperativity Index
0.9990
Equilibrium State
Favors T state at low [S]
MWC Model
The concerted model assumes all subunits exist in either R (relaxed, high affinity) or T (tense, low affinity) states, with transitions occurring simultaneously.