Maintenance Dose Calculator
Calculate the maintenance dose required to maintain steady-state drug concentration based on drug clearance and pharmacokinetic parameters.
Important Health Disclaimer
This calculator provides general health information based on standard medical formulas and WHO guidelines. Results are for informational and educational purposes only and should not be considered as professional medical advice, diagnosis, or treatment recommendations.
For health concerns, medical conditions, fitness plans, or dietary decisions, please consult with qualified healthcare professionals, licensed physicians, registered dietitians, or certified fitness trainers who can evaluate your individual health status and medical history.
Individual health needs vary significantly. These calculations are general estimates and may not be appropriate for everyone, especially those with existing medical conditions, pregnant women, children, or elderly individuals.
Not a substitute for professional medical advice
Patient & Drug Parameters
Desired steady-state concentration
Time between doses (e.g., 8 for TID)
Dose Per Interval
480.0 mg
Every 8 hours (3 times daily)
Formula
Dose = (Cl Γ Cpss Γ tau) / (F Γ S)
Where tau = dosing interval, Cl = clearance, Cpss = target concentration
Dosing Summary
Give 480.0 mg every 8 hours
Total daily dose: 1440.0 mg/day
Clearance used: 6.00 L/hr
Pharmacokinetic Principles
Steady State
- Reached after 4-5 half-lives
- Input rate = Output rate
- Drug accumulates until equilibrium
- Loading dose can achieve Cpss immediately
Dosing Intervals
- QD (once daily): 24 hours
- BID (twice daily): 12 hours
- TID (three times daily): 8 hours
- QID (four times daily): 6 hours
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Related Calculators
sources
- β’World Health Organization (WHO) β Global health metrics, disease classification, and nutritional standards. who.int
- β’Centers for Disease Control and Prevention (CDC) β Health statistics, BMI guidelines, and disease prevention data. cdc.gov
- β’National Institutes of Health (NIH) β Medical research, clinical guidelines, and health calculators. nih.gov
- β’Mayo Clinic β Clinical health information, disease reference, and wellness guidance. mayoclinic.org
For a complete list of all references used across the site, visit our full sources page.
Editorial Note
MyCalcBuddy Editorial Team
This page is maintained as an educational calculator reference.
Formula Source: WHO Health Metrics Standards
by World Health Organization