Tm Calculator

Calculate DNA melting temperature for primers and oligonucleotides.

Primer Sequence

Enter A, T, G, C only (other characters ignored)

Melting Temperature (Tm)

29.7C
Annealing: 24.7C (Tm - 5)

Sequence Properties

Length20 bp
GC Content50.0%
Molecular Weight6117 Da

Base Composition

A
5
T
5
G
5
C
5

PCR Guidelines

Optimal primer length: 18-25 bp

Optimal GC content: 40-60%

Optimal Tm: 55-65C

Primer pair Tm difference: max 5C

3' end: End with G or C (GC clamp)